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70 yo, F
Multilocular radiolucency involving the posterior mandible
The incisional biopsy consisted of a 1 cm in the area of the lesion. It was bisected longitudinally and entirely submitted.
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- The most common odontogenic tumour, excluding odontomas
- age range of 8–92 years and no sex predilection
- Approximately 80%: mandible; posterior region,
- Followed by the anterior mandible, posterior maxilla, and anterior maxilla
- Desmoplastic ameloblastoma: the anterior region of the jaws, especially the maxilla
- Wide surgical excision with usually 1.5 cm beyond the radiographic margin
- Conservative surgery: A high recurrence rate
- BRAF inhibitor treatment has been proposed, alone or in combination with MAPK/ERK kinase inhibitors
- Ameloblastoma is a benign but locally infiltrative epithelial odontogenic neoplasm
- No cytological atypia
- It may develop multiple growth patterns (unicystic, multicystic-solid/conventional, peripheral) and histopathological variants (basaloid, acanthomatous, follicular, plexiform, desmoplastic, granular).
- Most tumors have a mixture of histopathological variants.
- The standard of care is complete excision with negative margins irrespective of the histopathological variants.