29 yo, F
An expansile mixed radiolucent/radiopaque lesion in the posterior maxilla
The specimen consisted of solid mass fragments.
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CALCIFYING EPITHELIAL ODONTOGENIC TUMOUR
- ≤ 1% of OT
- No gender predilection
- Any age, with a predilection for third to sixth decade of life (mean:40)
- The mandible is affected twice as often as the maxilla
- Local surgical removal with tumour-free margin
- Recurrence: 15%
- A Congo red stain is useful to confirm the presence of odontogenic ameloblastic associated protein, a substance histologically identical to amyloid
- Due to the rarity of these lesions, pathologists should be aware of the ‘pseudo pleomorphism’ of the tumour cells.
- The Ki-67 index is low in benign lesions, reported as less than 2%. In a case of malignant transformation, the Ki-67 rose to 42% in tumor cells.